Structure validation

{{short description|Process of evaluating 3-dimensional atomic models of biomacromolecules}}

{{short description|Process of evaluating 3-dimensional atomic models of biomacromolecules}}

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{{cleanup reorganize|date=May 2019}}

{{cleanup reorganize|date=May 2019}}

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[[Image:Structure validation concept.jpg|thumb|right|Structure validation concept: model of a protein (each ball is an atom), and magnified region with electron density data and 3 bright flags for problems]]

[[Image:Structure validation concept.jpg|thumb|right|Structure validation concept: model of a protein (each ball is an atom), and magnified region with electron density data and 3 bright flags for problems]]

'''Macromolecular structure validation''' is the process of evaluating reliability for 3-dimensional atomic models of large biological molecules such as [[proteins]] and [[nucleic acids]]. These models, which provide 3D coordinates for each atom in the molecule (see example in the image), come from [[structural biology]] experiments such as [[x-ray crystallography]]<ref name="Rupp">{{harvnb|Rupp|2009}}</ref> or [[nuclear magnetic resonance]] (NMR).<ref name="Cavanagh">{{harvnb|Cavanagh

'''Macromolecular structure validation''' is the process of evaluating reliability for 3-dimensional atomic models of large biological molecules such as [[proteins]] and [[nucleic acids]]. These models, which provide 3D coordinates for each atom in the molecule (see example in the image), come from [[structural biology]] experiments such as [[x-ray crystallography]]<ref name="Rupp">{{harvnb|Rupp|2009}}</ref> or [[nuclear magnetic resonance]] (NMR).<ref name="Cavanagh">{{harvnb|Cavanagh