Mouse hosts produce functional rat sperm, opening new doors for genetic research

Rie Natsume and her collaborators person precocious developed an innovative and cost-effective method for generating rats that inherit traits from embryonic stem (ES) cells. Unlike rodent ES cells, rat ES cells person unsuccessfully been established and maintained successful civilization without losing pluripotency. Moreover, producing germline-transmitting chimeric rats from ES cells has been a large challenge, resulting successful lone a fistful of palmy reports.