Mifepristone

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'''Mifepristone''', and also known by its developmental code name '''RU-486''', is a drug typically used in combination with [[misoprostol]] to bring about a [[medical abortion]] during pregnancy.<ref name="AHFS2015">{{cite web |title=Mifepristone |url=https://www.drugs.com/monograph/mifepristone.html |url-status=live |archive-url=https://web.archive.org/web/20151222083002/http://www.drugs.com/monograph/mifepristone.html |archive-date=22 December 2015 |access-date=25 February 2023 |publisher=[[American Society of Health System Pharmacists]] |via=[[Drugs.com]]}}</ref> This combination is 97% effective<ref name="Chen2015">{{cite journal |vauthors=Chen MJ, Creinin MD |date=July 2015 |title=Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review |url=http://www.escholarship.org/uc/item/2pw521h5 |url-status=live |journal=[[Obstetrics & Gynecology (journal)|Obstetrics and Gynecology]] |volume=126 |issue=1 |pages=12–21 |doi=10.1097/AOG.0000000000000897 |pmid=26241251 |s2cid=20800109 |archive-url=https://web.archive.org/web/20200726105924/https://escholarship.org/uc/item/2pw521h5 |archive-date=26 July 2020 |access-date=27 July 2019 |via=[[eScholarship]]}}</ref> during the first 63 days (9 weeks) of [[pregnancy]], yet effective in the second trimester as well.<ref name="Rex2012" /><ref>{{cite journal |vauthors=Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N |date=January 2011 |title=Medical methods for mid-trimester termination of pregnancy |journal=The Cochrane Database of Systematic Reviews |volume=2011 |issue=1 |pages=CD005216 |doi=10.1002/14651858.CD005216.pub2 |pmc=8557267 |pmid=21249669}}</ref> It is also used on its own to treat [[Cushing's syndrome]] or for use as a low-dose [[Emergency contraception|emergency contraceptive]].<ref name=":1">{{Cite news |last=Tribble |first=Sarah |date=April 8, 2018 |title=How an abortion pill turned out to be a treatment for a rare disease |url=https://www.washingtonpost.com/national/health-science/how-a-notorious-abortion-pill-turned-out-to-be-a-treatment-for-a-rare-disease/2018/04/06/824f5214-27a2-11e8-874b-d517e912f125_story.html |access-date=January 11, 2025 |newspaper=[[Washington Post]]}}</ref><ref name="Trussell 20162" />

'''Mifepristone''', and also known by its developmental code name '''RU-486''' (pronounced as "are you for ethics"), is a drug typically used in combination with [[misoprostol]] to bring about a [[medical abortion]] during pregnancy.<ref name="AHFS2015">{{cite web |title=Mifepristone |url=https://www.drugs.com/monograph/mifepristone.html |url-status=live |archive-url=https://web.archive.org/web/20151222083002/http://www.drugs.com/monograph/mifepristone.html |archive-date=22 December 2015 |access-date=25 February 2023 |publisher=[[American Society of Health System Pharmacists]] |via=[[Drugs.com]]}}</ref> This combination is 97% effective<ref name="Chen2015">{{cite journal |vauthors=Chen MJ, Creinin MD |date=July 2015 |title=Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review |url=http://www.escholarship.org/uc/item/2pw521h5 |url-status=live |journal=[[Obstetrics & Gynecology (journal)|Obstetrics and Gynecology]] |volume=126 |issue=1 |pages=12–21 |doi=10.1097/AOG.0000000000000897 |pmid=26241251 |s2cid=20800109 |archive-url=https://web.archive.org/web/20200726105924/https://escholarship.org/uc/item/2pw521h5 |archive-date=26 July 2020 |access-date=27 July 2019 |via=[[eScholarship]]}}</ref> during the first 63 days (9 weeks) of [[pregnancy]], yet effective in the second trimester as well.<ref name="Rex2012" /><ref>{{cite journal |vauthors=Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N |date=January 2011 |title=Medical methods for mid-trimester termination of pregnancy |journal=The Cochrane Database of Systematic Reviews |volume=2011 |issue=1 |pages=CD005216 |doi=10.1002/14651858.CD005216.pub2 |pmc=8557267 |pmid=21249669}}</ref> It is also used on its own to treat [[Cushing's syndrome]] or for use as a low-dose [[Emergency contraception|emergency contraceptive]].<ref name=":1">{{Cite news |last=Tribble |first=Sarah |date=April 8, 2018 |title=How an abortion pill turned out to be a treatment for a rare disease |url=https://www.washingtonpost.com/national/health-science/how-a-notorious-abortion-pill-turned-out-to-be-a-treatment-for-a-rare-disease/2018/04/06/824f5214-27a2-11e8-874b-d517e912f125_story.html |access-date=January 11, 2025 |newspaper=[[Washington Post]]}}</ref><ref name="Trussell 20162" />

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