IFI44L

{{short description|Human gene}}

{{Infobox gene}}

{{Infobox gene}}

The '''''interferon-induced protein 44-like gene''''' (i.e., '''''IFI44L''''' gene, also known as the '''GS3686, TLDC5B,''' and '''C1orf29''' gene https://www.wikidata.org/wiki/Q18035986) codes for the interferon-induced protein 44-like protein (i.e., IFI44L protein). This gene is located in [[Karyotype#Types of banding|band]] 1, region 1 (see [[Locus (genetics)#Nomenclature|band and gene nomenclature]]) on the short, i.e., [[p arm|"p"]], arm of [[chromosome 1]] (location abbreviated as 1p31.1). A closely related gene, the ''interferon-induced protein 44 gene'' (i.e. the ''IFI44'' gene), is a [[Sequence homology#paralogy|paralog]] of the ''IFI44L'' gene (i.e., the two genes are duplicates of an ancestorial gene).<ref name="pmid35798818">{{cite journal | vauthors = Lee Y, Riskedal E, Kalleberg KT, Istre M, Lind A, Lund-Johansen F, Reiakvam O, Søraas AV, Harris JR, Dahl JA, Hadley CL, Jugessur A | title = EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infection | journal = Scientific Reports | volume = 12 | issue = 1 | pages = 11478 | date = July 2022 | pmid = 35798818 | pmc = 9261254 | doi = 10.1038/s41598-022-15467-1 | bibcode = 2022NatSR..1211478L | url = }}</ref> The IFI44L and IFI44 proteins are composed of 452 and 444 [[amino acids]], respectively, share 45% amino acid identity along with 60% [[Homology (biology)|homology]] at the amino acid level, and have many similar or overlapping functions and activities.<ref name="pmid38989827">{{cite journal | vauthors = Rupa D, Chuang HW, Hu CE, Su WM, Wu SR, Lee HS, Yuan TC | title = ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells | journal = Cancer Science | volume = 115 | issue = 9 | pages = 3026–3040 | date = September 2024 | pmid = 38989827 | pmc = 11462949 | doi = 10.1111/cas.16236 | url = }}</ref><ref name="pmid31434731">{{cite journal | vauthors = DeDiego ML, Martinez-Sobrido L, Topham DJ | title = Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses | journal = Journal of Virology | volume = 93 | issue = 21 | pages = | date = November 2019 | pmid = 31434731 | pmc = 6803278 | doi = 10.1128/JVI.01159-19 | url = }}</ref> This article focuses on the function and clinical significance of the ''IFI44L'' gene and the IFI44L protein that it directs to be formed.

The '''''interferon-induced protein 44-like gene''''' (i.e., '''''IFI44L''''' gene, also known as the '''GS3686, TLDC5B,''' and '''C1orf29''' gene https://www.wikidata.org/wiki/Q18035986) codes for the interferon-induced protein 44-like protein (i.e., IFI44L protein). This gene is located in [[Karyotype#Types of banding|band]] 1, region 1 (see [[Locus (genetics)#Nomenclature|band and gene nomenclature]]) on the short, i.e., [[p arm|"p"]], arm of [[chromosome 1]] (location abbreviated as 1p31.1). A closely related gene, the ''interferon-induced protein 44 gene'' (i.e. the ''IFI44'' gene), is a [[Sequence homology#paralogy|paralog]] of the ''IFI44L'' gene (i.e., the two genes are duplicates of an ancestorial gene).<ref name="pmid35798818">{{cite journal | vauthors = Lee Y, Riskedal E, Kalleberg KT, Istre M, Lind A, Lund-Johansen F, Reiakvam O, Søraas AV, Harris JR, Dahl JA, Hadley CL, Jugessur A | title = EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infection | journal = Scientific Reports | volume = 12 | issue = 1 | pages = 11478 | date = July 2022 | pmid = 35798818 | pmc = 9261254 | doi = 10.1038/s41598-022-15467-1 | bibcode = 2022NatSR..1211478L | url = }}</ref> The IFI44L and IFI44 proteins are composed of 452 and 444 [[amino acids]], respectively, share 45% amino acid identity along with 60% [[Homology (biology)|homology]] at the amino acid level, and have many similar or overlapping functions and activities.<ref name="pmid38989827">{{cite journal | vauthors = Rupa D, Chuang HW, Hu CE, Su WM, Wu SR, Lee HS, Yuan TC | title = ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells | journal = Cancer Science | volume = 115 | issue = 9 | pages = 3026–3040 | date = September 2024 | pmid = 38989827 | pmc = 11462949 | doi = 10.1111/cas.16236 | url = }}</ref><ref name="pmid31434731">{{cite journal | vauthors = DeDiego ML, Martinez-Sobrido L, Topham DJ | title = Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses | journal = Journal of Virology | volume = 93 | issue = 21 | pages = | date = November 2019 | pmid = 31434731 | pmc = 6803278 | doi = 10.1128/JVI.01159-19 | url = }}</ref> This article focuses on the function and clinical significance of the ''IFI44L'' gene and the IFI44L protein that it directs to be formed.